Discussion in 'Fitness & Nutrition' started by ludeboye, Mar 27, 2007.
I wonder the sides
Worked for this guy
7month old baby
Am J Physiol Cell Physiol. 2002 Jul;283(1):C135-41. Related Articles, Links
Single cysteine to tyrosine transition inactivates the growth inhibitory function of Piedmontese myostatin.
Berry C, Thomas M, Langley B, Sharma M, Kambadur R.
Animal Genomics, AgResearch, Hamilton, New Zealand.
Myostatin, a member of the transforming growth factor-beta superfamily, is a secreted growth factor that is proteolytically processed to give COOH-terminal mature myostatin and NH2-terminal latency-associated peptide in myoblasts. Piedmontese cattle are a heavy-muscled breed that express a mutated form of myostatin in which cysteine (313) is substituted with tyrosine. Here we have characterized the biology of this mutated Piedmontese myostatin. Northern and Western analyses indicate that there is increased expression of myostatin mRNA and precursor myostatin protein in the skeletal muscle of Piedmontese cattle. In contrast, a decrease in mature myostatin was observed in Piedmontese skeletal muscle. However, there is no detectable change in the circulatory levels of mature myostatin in Piedmontese cattle. Myoblast proliferation assay performed with normal and Piedmontese myostatin indicated that mature wild-type myostatin protein inhibited the proliferation of C2C12 myoblasts. Piedmontese myostatin, by contrast, failed to inhibit myoblast proliferation. In addition, when added in molar excess, Piedmontese myostatin acted as a potent "competitive inhibitor" molecule. These results indicate that, in Piedmontese myostatin, substitution of cysteine with tyrosine results in the distortion of the "cystine knot" structure and a loss of biological activity of the myostatin. This mutation also appears to affect either processing or stability of mature myostatin without altering the secretion of myostatin.
By injecting the purified Piedmontese Myostatin, one could technically decrease the activity of endogenous myostatin, thus creating a myostatin blocker that actually works.
I read couple of articles before posting this thread this is creepy shit
but we are not cattle
chemically we are pretty similar
i am not a cow
It doesn't do ANYTHING. You CANNOT change your genes by taking a supplement or even a drug.
Ya missed the point
Injection, it would be like drinking GH. If a real myostain blocker does come out it will most likely be injection also
Two cows are grazing in a field.
One cow says to the other, "I don't know about you, but I'm pretty worred about that mad cow disease that's going around."
The other cow says, "Nah, I'm not worried. I'm a helicopter."
damn...have to find an understanding as to how cows and it's mad disease is synonymous to helicopters...
If a person thought they were a helicopter they might be classified as crazy or also ...
if you could block myostatin it would likely have a bunch of negative health effects
god dude point of the joke was he already had the disease thats why he thought he was a helicopter. i love that joke
two muffins are in an oven.
one muffin says to the other muffin "wow it's really hot in here!"
the seond muffin says "holy shit, a talking muffin!!"
so this guy walked into a bar
I'd wait for Wyeth's clinical trial's (phase I and II) results to be released before you make assumptions. Besides, the boy with mutation apparently has no adverse effects as far as I've read.
Wyeth already has one in the product pipeline. MYO-029. It works off the premise off an antibiotic so it is not permanent gene therapy. Too bad no results have come out yet. (they're supposed to soon.)
maybe not with this but with other gene therapies in the future.