Let me start out with a little background info. I've been depressed for a few years now, but i was only perscribed prozac january of last year, so about a year ago. since then i haven't really felt the effects of it until recently, and they have gradually increased the dose from 10 to 40mg per day. I started smoking weed sometime in october, and i didn't really feel any worse when i only did it a few times a week. I started smoking a lot more, culminating at a few times a day around new years. Because of final exams, i (wisely) decided to take a break, and didn't smoke for about two weeks. During that two weeks, i felt progressively better, as in my general mood, and my confidence in social situations, and self esteem wise. This, in conjunction with the fact that my psychiatrist tells me studies have been done that show that weed decreases the effectiveness of prozac, leads me to believe that quitting smoking would cause me to become less depressed. Another thing that supports this is that i smoked for the first time in about two weeks on thursday, and a good amount of the day after i felt horrible, like i didn't want to talk to anyone, and that no one really likes me. Just generally a lot more depressed. I don't want to give up smoking totally because i enjoy it a lot, so i decided to perhaps cut back to once a week or so, and see if this doesn't affect my medication as much. Basically the point of this thread was to see if anyone has any input/experience with this, or if there actually are studies to support this. Sorry for the long post, but i thought i might get some good answers here.