This isn't quite yet a success story - I'm just getting started, and I'd appreciate advice from others who have been here. I posted an earlier thread about my situation, which I'd rather not dig up because I was at rock bottom when I wrote it, but feel free to search if you want some background. About 5 years ago, I started seeing a psychologist for social anxiety - I was at the point where I couldn't leave my dorm without having a panic attack, since I felt I was being watched judged constantly. I was also diagnosed with dysthymia, but I chose not to medicate for either condition, and therapy was enough to fix the social anxiety. Now, this past August, I started at my first-choice grad school. Because of the aforementioned anxiety and depression, I had a poor undergrad experience, so I was determined to make the most of my new situation and changed my lifestyle radically. I became extremely social, involved myself in student organizations, participated in intramurals, started lifting and running, and ate more healthy food. By all accounts, I should have been the happiest I have ever been - I love my classes, have met some great friends, ended up with an awesome roommate - but I still felt down, although I knew it was irrational. I should probably mention that I'm 24, and have never been in a relationship, let alone had sex. All of my experiences came in the two years between undergrad and grad school - drunkenly made out with two girls, and went on dates with two (other) girls that didn't go anywhere. I'm in fairly decent (albeit thin) shape, and I've been told that I'm good looking and a sharp dresser. When I came to grad school, I expected my situation to improve substantially - everything is going so well in my life, and I'm doing things that I love, both in class and outside. Yet I still couldn't meet girls, and my internal monologue didn't help matters. I've always told myself that I'm unattractive, scrawny, and un-personable, so I've never had any sort of self-confidence. Yet I've somehow been able to cope with it until now. The breakdown came about a month ago, and it was in the middle of a perfect storm. My class was in the middle of our most intensive group project of the semester, at which point I stopped exercising and eating properly, and started drinking much more heavily. There was one girl who was showing interest in me, but she had just ended a very messy relationship (literally three days before), so I backed off a bit. We exchanged constant communication for a while, but then it tailed off, and I started agonizing that I had done something wrong. It wasn't about this girl in particular - just general despair that I'm terrible with women. I eventually started feeling full-blown depression, lost my appetite and had trouble sleeping, to the point where I would lay in bed for hours (with anxieties racing through my head) before finally falling asleep. The worst moment was when I was driving home from class, after calling multiple psychiatrists and being informed that none were taking patients. I started crying in my car, feeling despair that I wouldn't be able to get help and that I would die alone and unloved. However, that moment pushed me to call my old therapist, and he set me up with one of his acquaintances in my new town. I've been seeing her for the last 3 weeks and things have been going better, although I still have some anxieties. I finally met with a psychiatrist this past Monday and started on 50mg of Zoloft, and I'm hoping that it will take effect over winter break. I've also returned to exercising regularly and my diet is back to normal. The one upside to the whole ordeal is that I realized that I have many true friends here, and their support has been invaluable throughout the process. The funniest thing is that none of them suspected that I've been depressed, so apparently I can keep up a good facade. Anyways, I'm now on day three of Zoloft. I still have my anxieties, but I've been sleeping much better. How long does it usually take before I start seeing effects?