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Open Orphan to develop omicron model for US customer
"hVIVO's fight against the pandemic continues with the development of this new challenge agent,” said Open Orphan chief executive Yamin Khan
www.proactiveinvestors.com
Ultimately, the aim is to conduct a human challenge study next year to assess the efficacy of an inoculation created by Vaxart Inc (NASDAQ:VXRT) that can be administered orally rather than via a jab.
Before that, hVIVO must develop a challenge agent based on the omicron variant that can be safely administered to healthy volunteers.
Next Generation Covid Vaccine Update: Intranasal & Other Mucosal Vaxes - Absolutely Maybe
Mucosal vaccines are aimed at the mucosal membranes—the wet linings starting inside our noses and mouths. They can be sprays, drops, or…
absolutelymaybe.plos.org
Ceaze
he/him
- Jun 4, 2000
- 67,814
COVID Smell Loss Tops Severity as Cognitive Impairment Predictor
Persistent loss of smell is a better predictor of long-term cognitive impairment than severity of COVID-19 infection.
www.medscape.com
Association of the Fourth BNT162b Vaccine With SARS-CoV-2 Infection
This cohort study of health care workers in Israel evaluates whether a fourth BNT162b2 vaccine dose lowered breakthrough infection rates of SARS-CoV-2.
jamanetwork.com
Findings In this multicenter cohort study of 29 611 health care workers in Israel, the breakthrough infection rate among those who received 4 doses was 6.9% compared with 19.8% in those who received 3 doses.
Meaning These findings suggest that a fourth vaccine dose was effective in preventing breakthrough COVID-19 infections in health care workers, helping to maintain the function of the health care system during the pandemic.
the_antsy_honda
Sir, I protest...
Covid can rebound even in people who haven’t taken Paxlovid, study finds
A preprint study found that nearly a third of people with Covid experienced rebound symptoms and 12% tested positive again, regardless of whether they'd taken Paxlovid.
www.nbcnews.com
Das_Ubermensch
OT Supporter
More points in the "not just a cold" column. Betting research will find it can linger in the body causing rebound, long covid, and mutations. So people who think they've had covid and are in the clear are out infecting everyone.Covid can rebound even in people who haven’t taken Paxlovid, study finds
A preprint study found that nearly a third of people with Covid experienced rebound symptoms and 12% tested positive again, regardless of whether they'd taken Paxlovid.
Gotta go give blood to the trial clinic next week, gonna go ahead and tell them put me on the VIP list for that BA.5 juice 
Good maybe they can start to actually have a clinical definition beyond I’m coughing two days after a negative test and I’m debilitated
Hybrid immunity retained six months after SARS-CoV-2 exposure
Scientists hypothesize that lower death rates in COVID-19 patients may be due to hybrid immunity, as well as the reduced severity of Omicron infections.
www.news-medical.net
The SARS-CoV-2 receptor-binding domain (RBD) immunoglobulin G (IgG) antibody levels, as well as T-cell responses against the SARS-CoV-2 spike protein, following the second COVID-19 vaccine dose was associated with comparable immunity between COVID-19 patients and close contacts. Thus, participants who received COVID-19 booster vaccination without any history of prior COVID-19 also benefited from hybrid immunity.
A similar level of immunity was observed among individuals who were in close contact with asymptomatic and symptomatic infected persons.
Previously, long-term observational data was not available related to the reinfection rate in individuals who were exposed to SARS-CoV-2. In the present study, none of the participants were reinfected with SARS-CoV-2 during enrollment.Figure 3.
Low neutralization of Omicron BA.5 after four doses of mRNA COVID-19 vaccine
Researchers assessed the neutralization of SARS-CoV-2 Omicron variant after messenger ribonucleic acid (mRNA) vaccination.
www.news-medical.net
The study findings showed that four COVID-19 mRNA vaccine doses did not efficiently neutralize the SARS-CoV-2 Omicron BA.5 sublineage. However, there was sufficient vaccine-induced neutralization in the sera obtained after BA.5 breakthrough infection. The researchers believe that there is an urgent need for an updated COVID-19 vaccine that neutralizes the highly immune evasive SARS-CoV-2 Omicron BA.5 sublineage.