CREW SRS Official, NON-POL, Covid-19™ Thread. We're Endemic now! No more delusions of herd immunity.

Grape_Ape

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Sep 1, 2003
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The A
Open Orphan PLC (AIM:ORPH, OTC:OPORF) said its subsidiary hVIVO has been commissioned by a US vaccines group to develop the world’s first human challenge model for the omicron Covid variant.

Ultimately, the aim is to conduct a human challenge study next year to assess the efficacy of an inoculation created by Vaxart Inc (NASDAQ:VXRT) that can be administered orally rather than via a jab.

Before that, hVIVO must develop a challenge agent based on the omicron variant that can be safely administered to healthy volunteers.
 

Grape_Ape

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Sep 1, 2003
88,544
The A


Although the antibody titer against the spike receptor-binding domain (RBD) decreased significantly 8 months after the second vaccination, the number of memory B cells continued to increase, while the number of memory T cells decreased slowly. Memory B and T cells from unvaccinated infected patients showed similar kinetics. After the third vaccination, the antibody titer increased to the level of the second vaccination, and memory B cells increased at significantly higher levels before the booster, while memory T cells recovered close to the second vaccination levels. In memory T cells, the frequency of CXCR5+CXCR3+CCR6- cTfh1 was positively correlated with RBD-specific antibody-secreting B cells. Furthermore, T cell-dependent antibody production from reactivated memory B cells in vitro was correlated to the Tfh-like cytokine levels. For the response to variant RBDs, although 60%-80% of memory B cells could bind to the Omicron RBD, their binding affinity was low, while memory T cells show an equal response to the Omicron spike. Thus, the persistent presence of memory B and T cells will quickly upregulate antibody production and T cell responses after Omicron strain infection, which prevents severe illness and death due to COVID-19.
 

Grape_Ape

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Sep 1, 2003
88,544
The A
Question Was there a benefit of vaccinating health care workers with a fourth dose of BNT162b2 vaccine during the Omicron variant outbreak of the COVID-19 pandemic?

Findings In this multicenter cohort study of 29 611 health care workers in Israel, the breakthrough infection rate among those who received 4 doses was 6.9% compared with 19.8% in those who received 3 doses.

Meaning These findings suggest that a fourth vaccine dose was effective in preventing breakthrough COVID-19 infections in health care workers, helping to maintain the function of the health care system during the pandemic.
 
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Das_Ubermensch

OT Supporter
Jan 11, 2004
14,667
Fuck you CITY
More points in the "not just a cold" column. Betting research will find it can linger in the body causing rebound, long covid, and mutations. So people who think they've had covid and are in the clear are out infecting everyone.
 

Grape_Ape

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Sep 1, 2003
88,544
The A

The SARS-CoV-2 receptor-binding domain (RBD) immunoglobulin G (IgG) antibody levels, as well as T-cell responses against the SARS-CoV-2 spike protein, following the second COVID-19 vaccine dose was associated with comparable immunity between COVID-19 patients and close contacts. Thus, participants who received COVID-19 booster vaccination without any history of prior COVID-19 also benefited from hybrid immunity.

A similar level of immunity was observed among individuals who were in close contact with asymptomatic and symptomatic infected persons.

Previously, long-term observational data was not available related to the reinfection rate in individuals who were exposed to SARS-CoV-2. In the present study, none of the participants were reinfected with SARS-CoV-2 during enrollment.Figure 3.
 

Grape_Ape

OT Supporter
Sep 1, 2003
88,544
The A

The study findings showed that four COVID-19 mRNA vaccine doses did not efficiently neutralize the SARS-CoV-2 Omicron BA.5 sublineage. However, there was sufficient vaccine-induced neutralization in the sera obtained after BA.5 breakthrough infection. The researchers believe that there is an urgent need for an updated COVID-19 vaccine that neutralizes the highly immune evasive SARS-CoV-2 Omicron BA.5 sublineage.
 

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