Official, NON-POL, Covid-19™ Thread. We're Endemic now! Weekly deaths at the lowest since March 2020

hootpie

Well-Known Member
Oct 5, 2003
46,135
Northern California

SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy studies have suggested mechanisms driving acute anosmia, it remains unclear how SARS-CoV-2 causes persistent smell loss in a subset of patients. To address this question, we analyzed olfactory epithelial samples collected from 24 biopsies, including from nine patients with objectively quantified long-term smell loss after COVID-19. This biopsy-based approach revealed a diffuse infiltrate of T cells expressing interferon-γ and a shift in myeloid cell population composition, including enrichment of CD207+ dendritic cells and depletion of anti-inflammatory M2 macrophages. Despite the absence of detectable SARS-CoV-2 RNA or protein, gene expression in the barrier supporting cells of the olfactory epithelium, termed sustentacular cells, appeared to reflect a response to ongoing inflammatory signaling, which was accompanied by a reduction in the number of olfactory sensory neurons relative to olfactory epithelial sustentacular cells. These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss.

I wonder where else in the body gene expression is getting fucked with :eek3:
 
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Das_Ubermensch

OT Supporter
Jan 11, 2004
14,894
Fuck you CITY
Maybe China should retaliate by requiring negative anal swab tests from Americans and having them submit to a brutal sniffing by a Covid detecting dog :oopsie:
Here's the real reason why. Countries who test arrivals finding really high positivity. Bad look for Americans who think planes can filter out viruses.

 
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Das_Ubermensch

OT Supporter
Jan 11, 2004
14,894
Fuck you CITY

Grape_Ape

OT Supporter
Sep 1, 2003
90,280
The A

Trigger warning
“What emerged was the People’s C.D.C.”
Isn’t that lead by Ding Dong and that idiot Yaneer that said everyone in the world would have monkeypox within like 3 months or is that the “World Health Network” :rofl:
 
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the_antsy_honda

This is the story of a little ship...
Dec 17, 2001
77,022
California
A few people would say an immunity wall doesn't exist and we are slowly killing ourselves :coolugh:
I would guess a portion of that is people just aren't testing anymore. But then again, probably case severity is so minor now that testing isn't even something people are thinking about
 

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