Ceaze
he/him
- Jun 4, 2000
- 70,672
Ask Ethan: How Did The Entire Universe Come From Nothing?
And can scientists even agree on what 'nothing' means?
www.forbes.com
This really fucks with my mind
Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant
Posoleucel, an investigational allogeneic off-the-shelf T-cell therapy that simultaneously targets six different viruses, demonstrated promising antiviral efficacy and safety in a phase II study of patients who had undergone stem cell transplantation to treat their cancer or other blood diseases.
www.news-medical.net
Lab-Grown Retinas to Restore Vision Are a Step Closer to Human Trials
Scientists from the University of Wisconsin–Madison in the US have coaxed light-sensitive eye cells grown in a lab to reconnect after separation, an important step for transplantation into patients to treat various eye diseases.
www.sciencealert.com
CRISPR gene editing may help treat heart disease after a heart attack
Researchers say a new CRISPR gene editing therapy may help treat heart disease. The scientists also found evidence the therapy can help repair damaged tissue immediately after a heart attack.
www.medicalnewstoday.com
Newly discovered CRISPR immune system shuts down infected cells to thwart infection
In this interview, News Medical speaks to Assitant Professor Ryan Jackson about his latest work, published in tandem Nature papers, detailing the discovery of a new CRISPR immune system.
www.news-medical.net
Hertz increased its fleet of electric rental cars — then, its profits exploded
A key contributor was Hertz’s discovery that electric vehicles are between 50-60 percent cheaper to maintain than gasoline-powered cars.
www.thecooldown.com
Study uncovers a strong link between gut bacteria and development of Parkinson’s disease
Parkinson's disease may start in the gut and spread to the brain, a new study from the University of Surrey suggests.
www.news-medical.net
So I got accepted into a phase 3 clinical trial for a medication that (hopefully) will stop my fluctuating hearing loss. If anyone is interested I can post updates in this thread.
clinicaltrials.gov
SPI-1005 for the Treatment of Meniere's Disease - Full Text View - ClinicalTrials.gov
SPI-1005 for the Treatment of Meniere's Disease - Full Text View.
Pretty sure they've known gut biopsies show Parkinson's signs for over a decade.Study uncovers a strong link between gut bacteria and development of Parkinson’s disease
Parkinson's disease may start in the gut and spread to the brain, a new study from the University of Surrey suggests.www.news-medical.net
We will never be able to live on another planet. Here’s why | Aeon Essays
The scientific evidence is clear: the only celestial body that can support us is the one we evolved with. Here’s why
aeon.co
Really good read, also there is all the viruses, bacteria and fungi that we would encounter that we haven’t had millions of years to adapt toWe will never be able to live on another planet. Here’s why | Aeon Essays
The scientific evidence is clear: the only celestial body that can support us is the one we evolved with. Here’s why
ashzero
⛧
morrowalnut
OT Supporter
- Oct 28, 2004
- 47,841
Extraordinary Discovery May Substantially Change Our Understanding of the Mechanism of Photosynthesis
Light-Driven CO2 Assimilation by Photosystem II and Its Relation to Photosynthesis Photosynthesis is the greatest natural process converting sunlight into chemical energy on a massive scale and maintaining life on Earth. There are basically two successive stages of oxygenic photosynthesis, of which
scitechdaily.com
So my first update for the SPI-1005 which is a novel drug for Ménière’s disease which consists of fluctuating hearing loss, dizziness, vertigo, and nausea. It’s a really shitty disease that doctors believe I have but it’s still not well understood because my condition doesn’t follow the pattern of the disease. The House Clinic is probably one of the most prestigious institutes in the world dedicated to the most mysterious or inexplicable hearing loss and deafness but they haven’t figured me out either. They are probably going to enroll me in the trial that I quoted above.SPI-1005 for the Treatment of Meniere's Disease - Full Text View - ClinicalTrials.gov
SPI-1005 for the Treatment of Meniere's Disease - Full Text View.
Meniere Disease
Ménière disease is a balance disorder. It’s caused by an abnormality in part the inner ear called the labyrinth. Fluid build-up here can cause a severe spinning sensation (vertigo) and affect the hearing.
Here’s the questionnaire they sent me.
- Are you between the ages of 18-75?
- Do you have a diagnosis of Meniere’s disease?
- Have you experienced any of the following Meniere’s disease symptoms in the past 3 months?:
- Tinnitus
- Aural fullness
- Vertigo and/or dizziness
- Are you currently (or within the past 60 days) receiving IV or intratympanic ototoxic medications (such as chemotherapy including cisplatin, carboplatin, or oxaliplatin; aminoglycoside antibiotics including gentamicin, amikacin, tobramycin, kanamycin, or streptomycin; or loop diuretics including furosemide)?
- Have you ever received a diagnosis of otosclerosis?
- Have you ever received a diagnosis of vestibular schwannoma?
- Have you undergone any surgical treatments in your affected ear?
- Do you have any cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, neurological, or psychiatric diseases?
- Do you currently (or within the past 30 days) use systemic steroids?
- Do you currently (or within the past 7 days) use intratympanic steroids?
- Have you ever experienced hypersensitivity or idiosyncratic reactions to compounds related to ebselen?
- Are you currently pregnant or breastfeeding?
- Have you participated in another investigational drug or device study within the past 30 days?
- Are you currently or willing to adhere to the following:
- Males who are sexually inactive (abstinent), have surgical sterilization (vasectomy) at least 6 months prior to study enrollment, or use a barrier method (condom or diaphragm) with spermicide throughout the study period and 90-days following study completion
- Females of childbearing potential who are sexually inactive (abstinent) for 14 days prior to screening and throughout the study, or who use one of the following acceptable birth control methods:
- i. IUD in place for at least 3 months prior to study; or
- ii. Barrier method (condom or diaphragm) with spermicide for at least 14 days prior to screening through study completion; or
- iii. Stable hormonal contraceptive for at least 3 months prior to study and through study completion; or
- iv. Surgical sterilization (vasectomy) of partner at least 6 months prior to study enrollment
- Females of non-childbearing potential who are surgically sterile (bilateral tubal ligation with surgery at least 6 months prior to study enrollment; hysterectomy; or bilateral oophorectomy at least 2 months prior to study), or at least 1 year since last menses
morrowalnut
OT Supporter
- Oct 28, 2004
- 47,841
Good luck.
Our physiopathological labels are very useful, but they have limits. They're constantly changing in response to new discoveries. Many (all?) pathophysiological labels have subsequently been replaced by a set of more specific ones. Diseases that are not common have less research associated with them, and therefore any pathophysiological variations are less likely to be recognized, understood, or treated. By participating in the study you can help scientists and medical providers understand what's going on with certain hearing problems even better than they already do
Our physiopathological labels are very useful, but they have limits. They're constantly changing in response to new discoveries. Many (all?) pathophysiological labels have subsequently been replaced by a set of more specific ones. Diseases that are not common have less research associated with them, and therefore any pathophysiological variations are less likely to be recognized, understood, or treated. By participating in the study you can help scientists and medical providers understand what's going on with certain hearing problems even better than they already do
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It’s really a novel drug too like they identified Ménière’s in the 70s and no one has created a drug for it. So the FDA is fast tracking this. Hope I don’t get placebo it sucks having this shit. People go on disability cuz of this. They can’t get out of bed because of the constant dizziness and vertigo which is the last part of the disease
morrowalnut
OT Supporter
- Oct 28, 2004
- 47,841
The amount of money given to research any given diseases determined by its prevalence and its connection to unexpected imminent death. This is why we we learned how to do heart surgery before we learned how to do facelifts.It’s really a novel drug too like they identified Ménière’s in the 70s and no one has created a drug for it. So the FDA is fast tracking this. Hope I don’t get placebo it sucks having this shit. People go on disability cuz of this. They can’t get out of bed because of the constant dizziness and vertigo which is the last part of the disease
My mother has had otosclerosis for 4 decades, and had to be very proactive in order to get treated for it just enough to be functional
Profound Implications: New Research Challenges a 70-Year-Old Theory of Protein Folding
The findings of the study call into question a long-held belief about the way proteins fold within our cells and have significant ramifications for the treatment of illnesses connected to protein misfolding. A groundbreaking study by researchers at the Department of Energy's SLAC National Acceler
scitechdaily.com
Israeli scientists are aiming to produce the world’s first preventative drug designed to stop tumors causing secondary cancer, and say the active ingredient has shown more than 90 percent effectiveness in mice.
The Bar Ilan University research team produced a peptide — a chain of amino acids — made to stop cancer cells from entering the blood and therefore halting them from moving around the body.
Cedars-Sinai Cancer Breakthrough: Biological Pathway Identified That Leads Stem Cells To Die or Regenerate
Altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate, according to a new study led by Cedars-Sinai and the University of California, San Francisco (UCSF). The findings, to be published today (January 13) in the peer-reviewed journal
scitechdaily.com
That makes sense now that I think about it. Cuz with Ménière’s yes it’ll disable you but it won’t kill you
morrowalnut
OT Supporter
- Oct 28, 2004
- 47,841
Think about how fast a shitload of money got thrown into covid-19 research. I'm not saying they did the wrong thing but just to demonstrate the pointThat makes sense now that I think about it. Cuz with Ménière’s yes it’ll disable you but it won’t kill you