Update:
Having a semi-configurable CPU ally is an awesome addition, and after more play time the graphics are a little better than the genesis version but definably smoother. The special effects add more excitement to the game play.
Running the game on my 21" crt side monitor (It sits to the side of my desk, fucker is gigantic but where it sits you can't tell. I usually leave some show running on it all the time) in full screen isn't a problem and it seems to run better in full screen mode.
Game is fucking hard, got my ass handed to me and lost 3 lives to those two bastard chicks in the club from SoR3 first level. Hate those bitches, they're the sole reason I don't like SoR3 because they're too hard

Difficulty is not a bad thing though, I could always put it on easy I guess, dunno if there is an "easier" option or not.
The way the game works its stages is new, you have chances to go in directions sometimes and change the "route" you're heading through, neat addition.