The Oxford University coronavirus vaccine trial has been paused due to serious adverse reaction

CommanderFish

OT Supporter
Jan 9, 2011
48,010
South Jersey



A large, Phase 3 study testing a Covid-19 vaccine being developed by AstraZeneca and the University of Oxford at dozens of sites across the U.S. has been put on hold due to a suspected serious adverse reaction in a participant in the United Kingdom.

A spokesperson for AstraZeneca, a frontrunner in the race for a Covid-19 vaccine, said in a statement that the company’s “standard review process triggered a pause to vaccination to allow review of safety data.”

In a follow-up statement, AstraZeneca said it initiated the study hold. The nature of the adverse reaction and when it happened were not immediately known, though the participant is expected to recover, according to an individual familiar with the matter.

The spokesperson described the pause as “a routine action which has to happen whenever there is a potentially unexplained illness in one of the trials, while it is investigated, ensuring we maintain the integrity of the trials.” The spokesperson also said that the company is “working to expedite the review of the single event to minimize any potential impact on the trial timeline.”

An individual familiar with the development said researchers had been told the hold was placed on the trial out of “an abundance of caution.” A second individual familiar with the matter, who also spoke on condition of anonymity, said the finding is having an impact on other AstraZeneca vaccine trials underway — as well as on the clinical trials being conducted by other vaccine manufacturers.


Clinical holds are not uncommon, and it’s unclear how long AstraZeneca’s might last. But the progress of the company’s trial — and those of all Covid-19 vaccines in development — are being closely watched given the pressing need for new ways to curb the global pandemic. There are currently nine vaccine candidates in Phase 3 trials. AstraZeneca’s is the first Phase 3 Covid-19 vaccine trial known to have been put on hold.

Researchers running other trials are now looking for similar cases of adverse reactions by combing through databases reviewed by a so-called Data and Safety Monitoring Board, the second person said.

AstraZeneca only began its Phase 3 trial in the U.S. in late August. The U.S. trial is currently taking place at 62 sites across the country, according to clinicaltrials.gov, a government registry, though some have not yet started enrolling participants. Phase 2/3 trials were previously started in the U.K., Brazil, and South Africa.

There are a number of different reactions that can qualify as suspected serious adverse reactions, symptoms that require hospitalization, life-threatening illness and even death. It was also not immediately clear which clinical trial the adverse reaction occurred in, though a clear possibility is the Phase 2/3 trial underway in the U.K.

 

Kozzy McKoz

To fuck around is human, to find out is divine
Apr 11, 2005
28,834
LIBERAL UTOPIA OF MASSACHUSETTS
new liquid metal corona

t1000.jpg
 
  • Haha
Reactions: Twinsen

Jacko

Vote for Sale
OT Supporter
Oct 17, 2006
22,516
NYC
I still say testing is going to be what gets everything back to normal, not a vaccine.
an effective treatment would be enough. testing isnt going give people confidence that they do not have to worry about this over other things in their lives.
 

Grape_Ape

OT Supporter
Sep 1, 2003
91,804
The A
I'm thinking along the lines of a super cheap, rapid, accurate (saliva?) test. If we can all test ourselves easily and quarantine if required, it should help stop the spread.
Maybe in Canada land but a positive for a good majority of idiots in the USA means no big deal, party time
 

Jacko

Vote for Sale
OT Supporter
Oct 17, 2006
22,516
NYC
I'm thinking along the lines of a super cheap, rapid, accurate (saliva?) test. If we can all test ourselves easily and quarantine if required, it should help stop the spread.
definitely.

but what would make you feel comfortable to go back to your regular life? traveling, etc.

for me, it would be that i get corona, go to the doctor and get a prescription for X and ill be over it in a few days. I dont really care if i get it if it can be treated.
 

mollywhop

🤙 Dick was moist as fuck 🤙
OT Supporter
Feb 13, 2020
34,195
Blue Ridge Mountains
I don't want it at all so I'm more on the preventative side of things vs treatment. I mean at least until they figure out the long term effects of having the disease.
That’s where I’m at. I’m overall healthy, fairly young, and in great shape so it’s unlikely I’d die from it. I’m worried about some crazy neurological issue or worse for years or maybe forever
 
  • Like
Reactions: Boots

talontsiawd

OT Supporter
Sep 5, 2003
19,492
St.louis
It still blows my mind that it's not being taken seriously yet. I figured the initial stupidity would fade away and people would come to their senses as the body count climbed :(

Problem is these people get it, sick a couple days and go "see no big deal, iv a cold that was worse"
 
  • Like
Reactions: Boots

Users who are viewing this thread

About Us

  • Please do not post anything that violates any Local, State, Federal or International Laws. Your privacy is protected. You have the right to be forgotten. Site funded by advertising, link monetization and member support.
OT v15.8.1 Copyright © 2000-2022 Offtopic.com
Served by fu.offtopic.com

Online statistics

Members online
395
Guests online
58
Total visitors
453

Forum statistics

Threads
369,597
Messages
16,898,069
Members
86,875
Latest member
Theodor