The UK is now trialing DMT to treat depression

morrowasted

OT Supporter
Oct 28, 2004
45,327
https://www.theguardian.com/science...-dmt-to-be-trialled-in-uk-to-treat-depression

Quote:UK regulators have given the go-ahead for the first clinical trial of the use of the psychedelic drug dimethyltriptamine (DMT) to treat depression.

The trial will initially give the drug – known as the “spirit molecule” for the powerful hallucinogenic trips it induces – to healthy individuals, but it is expected to be followed by a second trial in patients with depression, where DMT will be given alongside psychotherapy.

Taking the drug before therapy is akin to shaking up a snow globe and letting the flakes settle, said Carol Routledge, chief scientific and medical officer at Small Pharma, the company running the trial in collaboration with Imperial College London.

“The psychedelic drug breaks up all of the ruminative thought processes in your brain – it literally undoes what has been done by either the stress you’ve been through or the depressive thoughts you have – and hugely increases the making of new connections.

“Then the [psychotherapy] session afterwards is the letting-things-settle piece of things – it helps you to make sense of those thoughts and puts you back on the right track. We think this could be a treatment for a number of depressive disorders besides major depression, including PTSD, treatment-resistant depression, obsessive-compulsive disorder, and possibly some types of substance abuse.”

DMT is found in several plants and is one of the active ingredients in ayahuasca, a bitter drink consumed during shamanistic rituals in South America and elsewhere. DMT is also available as a street drug in the UK, where it classified as a class A substance, carrying a maximum penalty of seven years in jail for possession and life imprisonment for supply.

The Medicines and Healthcare products Regulatory Agency (MHRA) approved the trial on Monday, and Small Pharma is currently involved in discussions with the Home Office, which must also give permission because DMT is a controlled substance.

The hope is that the initial trial, which aims to establish the lowest dose of DMT that elicits a psychedelic experience, could begin in January. It will involve 32 healthy volunteers, who have never previously taken a psychedelic drug, including ecstasy or ketamine. This will be followed by trial in 36 patients with clinical depression.

The treatment will be modelled on studies of psilocybin – the psychedelic ingredient in magic mushrooms – in depression. Here patients are brought into a clinic, where they undergo a “setting” session, during which the clinician primes them to open their mind to the drug, and ensures that they are comfortable and relaxed. Next, they are administered the drug, and once the psychedelic experience ends, the patient immediately undergo a session of psychotherapy.

The difference with DMT is that the psychedelic experience comes on faster and more intensely, but is over more quickly. “Whereas a psilocybin session takes all day – and if you’re doing two or even more of those, that’s a large time commitment – a DMT session, all in, will probably take under two hours,” said Peter Rands, Small Pharma’s CEO.

“We expect DMT to be rapid-acting, equivalent or perhaps even better than psilocybin, so within hours of a session you will get rapid relief [from your depression]. We also expect the effect to be sustained over a similar time period.”

One recent trial of psilocybin and psychotherapy found a continued reduction in patients’ depressive symptoms four weeks after taking the drug.

Previous studies of ayahuasca have also suggested that it might have an antidepressant effect, said Amanda Feilding, founder and director of the Oxfordshire-based Beckley Foundation, which designs and develops psychedelic drug research to inform global drugs policy.

“I myself don’t find DMT to be a very lovable compound, but it is definitely an interesting study to do,” she said. “It is a harsher compound than other psychedelics like psilocybin or LSD, where the experience is more like a flower opening and receiving what’s already inside you.

“DMT triggers a strong [psychedelic trip], where people experience what they call ‘the entities’ – they meet beings who seem to be real, like being in a dream. But it can rather take one over.”


Do you guys think DMT would make a good introduction to psychedelics? I honestly don't know. Sometimes I think an experience so intense yet brief that it doesn't have the space or time to be negative might just be the right recipe for healing.

I personally never got much out of DMT, but I wonder how I might have reacted differently had I done it at around this age, without any prior psychedelic experiences.

I can't help but wonder if part of having the right "set" for a psychedelic experience includes having enough of an identity already formed in order to be questioned, if that makes any sense. Put another way, there may be "network configurations" of the brain that respond more positively to the introduction of noise than others
 
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morrowasted

morrowasted

OT Supporter
Oct 28, 2004
45,327
DMT sounds fun. I'd like to meet the machine elves.
fun is definitely not how I would describe it. it's, um, an experience. it kicks in so fast you cant really have too bad of a time. with acid and shrooms a lot of people start feeling anxious on the comeup and that sets the whole stage for a bad experience. with DMT it's like... your whole body starts vibrating more and more rapidly and normal existence flickers and melts away within less than 45 seconds. it can be scary but once it fully kicks in, like I said... it's as if there is no chance for fear. to an extent, being afraid requires a sense of an identity, and of past and future. in the middle of a DMT trip, you are just rawdogging experience without that baggage. of course, the price of that freedom is that the experience you have is totally different from the one everyone else is having
 
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morrowasted

morrowasted

OT Supporter
Oct 28, 2004
45,327
molly for depression and/ptsd imho
I agree for PTSD, for sure. MDMA is probably the most drug therapy for that.

Depression.... maybe. different cases of "depression" have different underlying pathologies IMO and respond to different things. since the diagnosis is entirely based on subjective reports about behaviors and moods and subjective observations, it's hard to piece apart exactly how many different things are going wrong physically in the group of people that find themselves being labeled depressed

Some people respond to ketamine really well, Some people respond to wellbutrin really well, some people respond to paxil really. hell, some people who think they're depressed end up just having hypothyroidism and none of the first 3 treatments are right for them. if the underlying mechanism were the same in all of these people, it would be highly suspect that all these different treatments so different are capable of resolving it
 

brah pitt

i still owe money to the money to money i owe.
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May 2, 2007
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intro_vert13

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Feb 26, 2005
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an offshore haven somewhere
I agree for PTSD, for sure. MDMA is probably the most drug therapy for that.

Depression.... maybe. different cases of "depression" have different underlying pathologies IMO and respond to different things. since the diagnosis is entirely based on subjective reports about behaviors and moods and subjective observations, it's hard to piece apart exactly how many different things are going wrong physically in the group of people that find themselves being labeled depressed

Some people respond to ketamine really well, Some people respond to wellbutrin really well, some people respond to paxil really. if the underlying mechanism were the same in all of these people, it would be highly suspect that 3 treatments so different are capable of resolving it
don't ever quote me again
 

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