I dont know how many Twin Peaks fans are here but its one of my favorite shows. Anyway - I was looking at Sheryl Lee's profile last night (Laura Palmer) and noticed that she is listed as "Additional Voices" for Bioshock 2. Now, if you've ever seen Twin Peaks, particularly the last episode and the movie prequel...you may remember how creepy this chick can be...but most importantly, she can scream like a mother fucker. She wasnt around much because she's found dead in episode 1 of the show, but she is an important part of the show throughout and you do see her here and there in weird ways. Anyway - when I was playing Bioshock 2, the first time I heard a Big Sister scream I was like "whoa that sounded like Laura Palmer's scream in the final episode of Twin Peaks" because I had seen it again recently, and I'll never forget it...it's a creepy one. She's not screaming in fear, she just starts screaming: ....and it sounds just like the Big Sister's scream... There is no credit for the Big Sister voice so I'm thinking it's pretty likely that they used her scream. I really would like to find out for sure. Maybe they even just took the audio from that episode of Twin Peaks. It's one of the scariest screams ever. You just feel uncomfortable hearing it, and I felt the same way when I heard the first Big Sister.....eiw.