I used to take Effexor, and honestly, I don't think it did a lot for my depression. It did cut down on some of the physical anxiety I felt, but I never really noticed a major difference with the depression. Since I got off it, I've been pretty much against antidepressants, but as of late, I've been extremely down, obsessing a ton, and I just really, really need something to help me. I never take part in my creative endeavors (writing, music) because I just never feel up to it. I put in minimal effort in everything else, and I really feel like I'm just wasting my life away (still). If it helps to know, I suffer from depression and OCD, and I could quite possibly be ADD/ADHD. So, which antidepressants have you taken/are you on, and which have worked well for you? I'm afraid of the sexual side effects, as I got those with Effexor. I hear Wellbutrin has the least.